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Do SSRI's I've always had great respect for this subreddit . 2 days ago Lots of studies say microdosing likely mostly placebo (and that's with mostly LSD, that has 50x stronger potency compared to psilocybin). 13 Nov 2020 “This placebo-controlled study indicates that fluvoxamine may prevent serious breathing problems in people with mild COVID-19 illness, and is responded to treatment with the SSRI citalopram (Celexa) were able to attain of an SSRI was better at alleviating depression than placebo augmentation. Reddit. ResearchGate Logo.

Jacobsen PL, Mahableshwarkar AR, Serenko M, Chan S, Trivedi MH. 1. Int J Neuropsychopharmacol. 2014 Aug;17(8):1149-57. doi: 10.1017/S1461145714000352. Epub 2014 Mar 26.

In fact there are number of studies that show how most of the perceived antidepressant and anxyolitic effect of SSRI is due to placebo: only 43% of study demonstrate that SSRI are more effective then placebo and a review of study suggest that until 82% of the perceived improvements is due to placebo.

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Epub 2014 Mar 26. Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder.

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Effects of prenatal maternal stress on serotonin and fetal development . 5-HT2cR antagonist reverses social deficits in mice . Cyproheptadine in treatment of autism . Cyproheptadine in the treatment of autistic disorder: a double-blind placebo … subscribe for freshly picked reddit content : http://bit.ly/2S0CKEC Title: What "placebo effect" do people not realize? - (r/AskReddit) See ALL My AskReddi 2019-07-18 2012-01-18 This study aimed to assess acceptability of combined sertraline plus mirtazapine treatment for PTSD and to estimate its effect size relative to sertraline plus placebo. Methods. Thirty‐six adults with PTSD were randomized to 24 weeks of double‐blind treatment with sertraline plus mirtazapine or sertraline plus placebo.

SSRI doses were 10 mg/day (escitalopram) and 20 mg/day (fluoxetine and paroxetine). Results: Compared to SSRI-treated patients, duloxetine-treated patients had a significantly greater (p < or = 0.05) reduction in the 17-item Hamilton Depression Rating Scale (HAMD17) total score and HAMD17 items of work and activities, psychomotor retardation, genital symptoms and hypochondriasis. CBC news covers the recent studies showing that Antidepressants were found to be no more effective than Placebo. The questions were asked why were these Anti 2014-07-07 · Placebo effect has consistently gotten stronger over the past few decades, such that the difference between certain early tricyclic studies (which often found strong advantages for the medication) and modern SSRI studies (which often find only weak advantages for the medication) is not weaker medication effect, but stronger placebo effect (that is, if medication always has an effect of 10, but This study aimed to assess acceptability of combined sertraline plus mirtazapine treatment for PTSD and to estimate its effect size relative to sertraline plus placebo. Methods. Thirty‐six adults with PTSD were randomized to 24 weeks of double‐blind treatment with sertraline plus mirtazapine or sertraline plus placebo.
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2020 Jun 1;10(1):159. doi: 10.1038/s41398-020-0844-4. PURPOSE Depression is common in primary care. There are no systematic reviews of depression treatment comparing antidepressants with placebo; hence, we do not know whether these medications are effective in primary care.

Analysis of efficacy was based on 3,047 subjects treated with an SSRI antidepressant and 3,740 subjects treated with a placebo. There was no statistically significant difference in effect size between the clinical trials that had a placebo run‐in phase followed by withdrawal of placebo responders and those trials that did not.
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doi: 10.1017/S1461145714000352. Epub 2014 Mar 26. Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder.